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Monthly Archives

July 2019

AOTD
July 31, 2019

Today’s Answer of the Day

The transdermal fentanyl patch is more often prescribed for baseline pain rather than breakthrough pain. Why? The fentanyl transdermal patch has a slow onset and long duration of action. Therapeutic…
AOTD
July 30, 2019

Today’s Answer of the Day

How is fentanyl metabolized? Fentanyl is metabolized via the cytochrome P450 (CYP) 3A4 system. Extreme caution must be taken when administering fentanyl, if the patient is on other medications that…
AOTD
July 29, 2019

Today’s Answer of the Day

What cautionary measures should be taken when prescribing fentanyl for breakthrough pain? Patients who are not opioid tolerant are at risk for developing severe hypoventilation, when given fentanyl for breakthrough…
AOTD
July 27, 2019

Today’s Answer of the Day

Do cannabinoids impact antiretroviral therapy-related nausea? Cannabinoids, such as dronabinol as well as non-pharmaceutical preparations, are commonly used by HIV and AIDS patients in an attempt to counter nausea caused…
AOTD
July 26, 2019

Today’s Answer of the Day

What is the "gold standard" tapering schedule for a patient who has been on long-term opioid therapy? There is no "gold standard" opioid tapering schedule. The tapering schedule should be…
AOTD
July 25, 2019

Today’s Answer of the Day

Is cannabinoid-based therapy likely to differentially affect Huntington's disease (HD) patients compared to other patient populations? The effect of cannabinoids on HD patients may be unique compared to other populations,…
AOTD
July 24, 2019

Today’s Answer of the Day

Is the endocannabinoid system involved in human epilepsy? Yes. There are defects in the endocannabinoid system in persons with epilepsy. In one study, 12 patients with newly diagnosed temporal lobe…
AOTD
July 23, 2019

Today’s Answer of the Day

Do clinical studies suggest that cannabis-based medicine can alleviate cancer pain? In animal models, cannabinoids have been shown to be synergistic with opioids in reducing pain. A small pharmacokinetic interaction…
AOTD
July 22, 2019

Today’s Answer of the Day

Have any cannabinoid medicines been withdrawn from the market because of an increased risk of suicide? Rimonabant, a cannabinoid medicine that selectively blocks CB1 receptors, was approved in the European…