November 2019

Excluding potential drug:drug interactions, what adverse effects of CBD have been noted in clinical trials? In clinical trials evaluating CBD, adverse effects, including diarrhea, somnolence, decreased appetite, change in weight,…

It is often stated that CBD is not psychoactive, but THC is psychoactive. Is that accurate? Is CBD psychoactive? Actually, both THC and CBD are psychoactive. By definition, a psychoactive…

Compare the analgesic effects of THC to codeine’s analgesic effects. The analgesic effectiveness of cannabinoids is comparable to that of the weak opioids.20 mg of THC is equianalgesic to about…

Even though THC and CBD have the same chemical formula ( C21H30O2 ), they differ structurally. How do they differ structurally? THC has a closed ring, while CBD has a…

Does THC bind to plasma proteins? Yes, THC is highly protein-bound, and thus might displace other drugs that are protein- bound. Although studies performed by a manufacturer of a THC:CBD…

Does CBD binds to several receptors outside of the endocannabinoid system? Yes. CBD is a partial agonist of the serotonin 5-HT1Areceptor, an agonist of the adenosine A2A receptor, an agonist…

In 2017, the National Academies of Sciences, Engineering and Medicine (NASEM) published The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. This report…

Does ingesting CBD with fatty food, as opposed without food impact the absorption of CBD? According to studies evaluating the metabolism of Epidiolex, (a CBD FDA-approved drug),consuming CBD with fatty…

How should cannabinoid-based therapy be withdrawn? According to Health Canada’s document entitled Information for Health Care Professionals: Cannabis and Cannabinoids, “If intolerable adverse effects appear without significant benefit, dosing should…

In addition to AIDS-associated anorexia, dronabinol is also used for the treatment of n/v associated with chemotherapy. What are the dosing ranges for dronabinol when used as an anti-emetic? For…