According to literature reviews, the use of marijuana is associated with an increased risk of thromboembolism. However, there is evidence that cannabinoids have an anticoagulant effect, as well. In addition, some cannabinoids (including THC and CBD) interact with anticoagulant agents such as warfarin, and increase the INR. These factors should be considered prior to performing neuroaxial blocks and placing invasive lines in patients who use marijuana.
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