August 2020

Does smoking marijuana impact the metabolism of theophylline? It may. Reports have indicated that smoking marijuana may increase the clearance of theophylline. Note: this effect appears to be a direct…

Do the hydrocarbons in marijuana smoke impact drug metabolism? Possibly. Similar to cigarette smoke, the hydrocarbons in marijuana smoke appear to induce the activity of some cytochromes, including CYP1A2. See…

What criteria should be used when selecting a CBD hemp product? According to a 2019 Mayo Clinic publication, the following 4 questions should be asked, and the answers to each…

Is full spectrum CBD the same as whole plant CBD? No. Whole plant CBD contains fats, waxes and fibrous materials not found in full spectrum CBD. See Answer See Answer

Is the plasma concentration of Epidiolex (CBD) affected by co-administration of high fat/high calorie food? Yes. It has been that if CBD is co-administered with a high fat/high calorie meal,…

Describe the exact mechanism of action of Epidiolex. According to the Epidiolex FDA Approved Package Insert, (Greenwich Biosciences, Inc.), the precise mechanism(s) by which Epidiolex exerts its anticonvulsant effects in…

Have the results of studies examining the impact of maternal marijuana use identified a unique phenotypic congenital anomaly? Studies evaluating maternal use of marijuana have not found a unique phenotypic…

Changes in fetal growth have been described in some epidemiological studies examining the impact of maternal use of marijuana. Do the long‐term patterns of physical growth appear to be affected?…

What is the safety profile of Olinvyk? According to an August 7, 2020 FDA news release, "The safety profile of Olinvyk is similar to other opioids. As with other opioids,…

What is oliceridine (Olinvyk)? Is it a new FDA-approved opioid? According to an August 7, 2020 FDA news release, "the FDA approved Olinvyk (oliceridine), an opioid agonist for the management…