Does the endocannabinoid system play a role in the modulation of associative fear learning? |
Yes. The endocannabinoid system is involved with learned fear and anxiety. For example, CB1 activation at the basolateral amygdala (BLA) modulates associative fear learning. (The BLA is involved with information storage and the formation of conditioned fear responses to previously neutral stimuli- neutral stimuli are paired with aversive stimuli.) Also, CB1 receptor in the area of the prefrontal networks modulate fear expression and fear extinction. |
| Anthony Murkar, Joseph De Koninck, Zul Merali, Cannabinoids: Revealing their complexity and role in central networks of fear and anxiety, Neuroscience & Biobehavioral Reviews, Volume 131, 2021, Pages 30-46, ISSN 0149-7634, https://www.sciencedirect.com/science/article/abs/pii/S0149763421003845?via%3Dihub |
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National Academies of Science, Engineering and Medicine. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington, DC: The National Academies Press; 2017.
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Shmerlig, Robert H., MD, 2015. Senior Faculty Editor. First, Do No Harm. Harvard Health Publishing.
Siddappa N. Byrareddy, Mahesh Mohan, 2020. SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation? Brain, Behavior, and Immunity 87 (2020) 120–121.
References:
What is the endocannabinoid system?
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Describe cannabinoid receptor -2.
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The terms cannabis, marijuana and hemp are often used interchangeably; however, the terms actually have different meanings. What is cannabis? What is marijuana? What is hemp? Is the hemp plant a cannabis plant?
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In 2017, the National Academies of Sciences, Engineering and Medicine(NASEM) published the Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Did the results of the research indicate that cannabis-based products are effective?
