In Australia, many jurisdictions use point-of-collection oral fluid testing devices (the DrugWipe®-5S and the Drug Test® 5000) to detect driving under the influence of cannabis (which is indexed by the presence of Δ9-THC in oral fluid). Can these devices used in Australia reliably distinguish between CBD and THC, which have similar chemical structures?
Yes. A randomized, double-blind, crossover design study with healthy participants (n = 17) determined that orally administered CBD does not appear to produce false-positive (or true-positive) tests for THC on the DrugWipe®-5S and the Drug Test® 5000. The participants completed four treatment sessions involving the administration of either placebo or 15mg, 300mg or 1500mg pure CBD in a high-fat dietary supplement. Oral fluid cannabinoid concentrations were measured using ultra-HPLC tandem mass spectrometry.
“McCartney D, Irwin C, Kevin R, Grunstein R. Orally administered cannabidiol (CBD) does not produce false‐positive tests