What medications alleviate the symptoms of marijuana withdrawal?
There are no general guidelines to treat the symptoms of marijuana withdrawal, but it has been reported that benzodiazepines and synthetic THC products used for the treatment of chemotherapy induced N/V may help alleviate some of the symptoms.
Alexander JC, Joshi GP. A review of the anesthetic implications of marijuana use. Proc (Bayl Univ Med Cent). 2019;32(3):364–371. Published 2019 May 21. doi:10.1080/08998280.2019.1603034
Is the endocannabinoid system linked to the opioid system?
Yes. Opioid receptors and cannabinoid receptors are located within the same neurons of the CNS. In addition, cannabinoids activate kappa and delta receptors to initiate a release of endogenous opioids.
What are the 5 most common mental health reasons medical marijuana patients use cannabinoid-based therapeutics?
According to a survey study involving 27,169 respondents (aged 16–65) across the US and Canada, the most common mental health reasons for the use of cannabis-based products include anxiety (52%), depression (40%), and PTSD/trauma (17%). There were 11% who reported using cannabis for managing other drug or alcohol use and 4% for psychosis.
What are the 5 most common physical health reasons medical marijuana patients use cannabinoid-based therapeutics?
According to a survey study involving 27,169 respondents (aged 16–65) across the US and Canada, the most common physical health reasons for the use of cannabinoid-based products include use to manage pain (53%), sleep (46%), headaches/migraines (35%), appetite (22%), and nausea/vomiting (21%).
According to an August 2022 Gallup poll, ~ 16% of Americans say they currently smoke marijuana. What percentage of Americans smoke tobacco? Is it greater than or less than the percentage of Americans who say they currently smoke marijuana?
The August 2022 Gallup poll states, “Today, a new low of 11% of American adults report being [tobacco] smokers. Roughly three in 10 non-smokers say they used to smoke.” “Cigarette smoking incidence has dropped steadily over the decades, from a high of 45% in the mid-1950s.”
According to an August 2022 Gallup poll, “some 16% of Americans say they currently smoke marijuana, while a total of 48% say they have tried it at some point in their lifetime. Marijuana use (based on self-reports) has increased dramatically over the past half-century. Only 4% said they had ever tried marijuana in 1969, when the question was first asked. That’s now 48%. Seven percent of Americans said they currently smoke marijuana in 2013, compared with the 16% measured this summer.”
What cardiac events have been seen in pediatric patients who consume edible recreational cannabis?
According to a retrospective analysis of the National Poison Data System data for pediatric exposures to edible cannabis products in children <6 years from 2017 to 2021, involving 7043 exposures, "tachycardia was seen in 548 cases (11.4%), whereas bradycardia was seen in 68 cases (1.4%)... Hypotension, in 123 cases (2.5%), was more common than hypertension, 43 cases (0.9%)."
Tweet MS, Nemanich A, Wahl M. Pediatric Edible Cannabis Exposures and Acute Toxicity: 2017–2021. Pediatrics. 2023;151(2):e2022057761