The endocannabinoid system has been described as a system composed of neurotransmitters and receptors. The receptors are found throughout the central nervous system and peripheral nervous system. Are receptors also found on non-nerve cells?
Yes. CB2 receptors are found throughout the immune system. They are present on B cells, T cells, and macrophages. Also, CB2 receptors are expressed on cells of the spleen, liver, kidneys and skin.
What percentage of 12th graders in the US have used marijuana at least once in their life?
According to the National Institute on Drug Abuse’s Monitoring the future, nearly one half of all 12th-graders in the United States have used marijuana in their lifetime, with more than one third during the past year, and almost one quarter in the past month.
Compared to previous years, has the number of opioid deaths since the COVID pandemic increased or decreased?
Since the beginning of the COVID-19 pandemic, a dramatic increase in the number of opioid overdose deaths has been reported. According to a recent report put out by the American Medical Association, opioid overdose deaths have increased in more than 35 states since the pandemic began. This surge is believed to be multifactorial, and due to isolation, economic issues, disruptions to the drug trade and other factors.
Did the abuse of non-opioid substances in combination with non-prescription fentanyl increase or decrease during the first 2 months of the COVID pandemic shutdown compared to earlier in 2020 and in 2019?
Abuse of non-opioid substances in combination with non-prescription fentanyl increased dramatically during the first two months of the COVID pandemic. For example, the use of non-prescription fentanyl: with amphetamines increased by 89% (P<0.01) , with benzodiazepines increased by 48% (P<0.01) , with cocaine increased by 34% (P<0.01)
Did abuse of non-prescription fentanyl increase or decrease during the first 2 months of the COVID pandemic shutdown compared to earlier in 2020 and in 2019?
According to an analysis of Quest Diagnostics data, non-prescription fentanyl abuse increased by 35% during the time period of March 15 to May 16, 2020 (P<0.01). Among males, the percentage of those positive for opioid use increased from 5.7% to 8.6%, while the rate for females increased from 3.2% to 3.7%. The positivity rate increased for all age groups. Of note, there was an increase from 10.2% to 13.4% for the 18 to 24 years old, age group.