AOTD

Some state medical marijuana dispensary systems are vertical systems. What does it mean to be a vertical system? In a vertical system, a dispensary is responsible for all aspects of…

Other than pill form, in what forms is CBD sold? There are multiple CBD product types, including CBD oils (for oral administration or vaporization), gummy candies, joint balms, creams, lotions,…

Cannabinoid-infused lotions, creams and ointments are sold in some medical marijuana dispensaries. Is topical administration an effective way to administer cannabinoids? Actually, No. Cannabinoids are hydrophobic and do not easily…

Are the amounts of the various cannabinoids in edibles consistent throughout a single baked product or throughout a batch of baked products. No. The amounts of the various cannabinoids in…

Is there solid clinical evidence to support that cannabinoids (natural or synthetic) can effectively and safely treat cancer in humans? No. See Answer See Answer

What factors influence the amount of cannabinoids delivered via vaporization? The amounts of THC and other cannabinoids delivered via vaporization are not only dependent on temperature, duration of vaporization and…

What adverse effects of CBD have been noted in clinical trials? In clinical trials evaluating CBD, adverse effects, including diarrhea, somnolence, decreased appetite, and increased levels of liver enzymes have…

Is cannabidiol metabolized or excreted without being metabolized? Cannabidiol is metabolized in liver microsomes by cytochrome P450 (CYP) 2C19 to an active metabolite 7-hydroxy-cannabidiol (7-OH- CBD). 7-OH-CBD is further metabolized…

Does CBD influence endocannabinoid levels? Yes. CBD decreases the FAAH (fatty acid amide hydrolase )-mediated and MAGL (monoacylglycerol lipase)-mediatedhydrolysis of endocannabinoids. Also, CBD inhibits the cellular re-uptake of endocannabinoids by…

What is Nabiximols? Nabiximols is an oromucosal spray containing a 1:1 ratio of THC:CBD as well as specific minor phytocannabinoids and other non-cannabinoid plant components. Nabiximols has been approved for…