Your Dose of Cannabis Education
Your Dose of Cannabis Education
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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education.
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2025-11-13
Sertraline is a commonly prescribed selective serotonin reuptake inhibitor (SSRI) to treat depression, anxiety, OCD, PTSD and/or other ailments. Many people with depression, anxiety, OCD and/or PTSD also consume cannabinoid-based medicines to treat their symptoms. Could the metabolism of sertraline be impacted by THC?
Yes, THC inhibits CYP3A4, the enzyme that metabolizes sertraline, and therefore the co-administration of THC and sertraline may result in an increased availability of sertraline.Current Psychiatry. 2021 May;20(5):21-23, 28-33 | doi:10.12788/cp.0121, and MD Raphael J. Leo Raymond M. St. Marie. "Cannabinoid-Based Medications for Pain." MDedge Psychiatry, 3 May 2021.
2025-11-12
If a lactating woman is consuming cannabis, should she be told to stop breastfeeding?
According to ACOG's Clinical Consensus No. 10: Cannabis Use During Pregnancy and Lactation, "Obstetrician–gynecologists and other obstetric health care professionals should advise cessation of cannabis use during pregnancy and lactation. However, continued cannabis use is not a contraindication to breastfeeding, and breastfeeding should not be discouraged." ("it is important to note that breastfeeding has numerous health effects, including decreased rates of infection, asthma, and obesity and improved intellectual development.")ACOG Clinical Consensus No. 10: Cannabis Use During Pregnancy and Lactation. Obstetrics & Gynecology 146(4):p 600-611, October 2025. | DOI: 10.1097/AOG.0000000000006053
2025-11-10
What are some of the risks associated with the consumption of cannabis during pregnacy?
"Cannabis exposure during pregnancy has been associated with low birth weight, small-for-gestational-age neonates, neonatal intensive care unit admission, and perinatal mortality. Neonates exposed to cannabinoids in utero also demonstrate altered arousal patterns, regulation, and excitability in the first month of life....[Some] studies suggest potential risk for postnatal neurocognitive and behavioral dysfunction, including attention deficit disorders, behavioral and short-term memory challenges, and intellectual disabilities. "
ACOG Clinical Consensus No. 10: Cannabis Use During Pregnancy and Lactation. Obstetrics & Gynecology 146(4):p 600-611, October 2025. | DOI: 10.1097/AOG.0000000000006053
2025-11-07
Has any national drug administration approved a CBD-containing product for therapeutic use in conditions other than epilepsy?
Yes. The oromucosal spray Sativex (nabiximols) is a cannabis extract that contains the principal cannabinoids delta-9-tetrahydrocannibinol (THC) and cannabidiol (CBD) in a 50:50 ratio, as well as specific minor cannabinoids and other non-cannabinoid components. Regulatory approval has been obtained in numerous countries outside the United States for the treatment of multiple sclerosis symptoms (nerve pain, spasticity, overactive bladder, and other symptoms). GW Pharmaceuticals website. Sativex. https://www.gwpharm.com/healthcare-professionals/sativex
2025-11-06
If a parturient consumes cannabis, does THC get excreted in the breastmilk?
Yes, and in fact, "THC can be found in breast milk for up to 6 days after maternal consumption, [and ]it may be concentrated up to sevenfold compared with maternal plasma in chronic consumption....The relative infant dose, the amount absorbed, has been estimated to be 2.5% (range 0.4%–8.7%) of the maternal dose."Shah S, Schwenk ES, Sondekoppam RV, et al. ASRA Pain Medicine consensus guidelines on the management of the perioperative patient on cannabis and cannabinoids. Regional Anesthesia & Pain Medicine Published Online First: 03 January 2023. doi: 10.1136/rapm-20
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