Your Dose of Cannabis Education
Your Dose of Cannabis Education
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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education.
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2025-11-03
Which meal improves CBD bioavailability more - a high fat or a high carbohydrate meal?
Data from clinical studies indicate that "..a prior high-fat meal enhances CBD bioavailability more than an energy matched high-carbohydrate meal. Therefore, timing CBD ingestion after high-fat meals may be an advantageous strategy to maximise the efficacy of CBD supplementation. "Cunha MFD, Funnell MP, Johnson DA, Nickels M, Bailey SJ, Heaney LM, and James LJ (2025). A prior high-fat meal increases plasma cannabidiol concentrations compared to an isoenergetic high- carbohydrate meal in healthy young participants: a randomised crossover study. Proceedings of the Nutrition Society 84(OCE4): E254. doi: 10.1017/S0029665125101262
2025-10-31
Have researchers found that epilepsy patients who use a CBD-rich extract require a lower dose of CBD as compared to those who use purified CBD?
According to a clinical study, “the average dose described by [epilepsy] patients taking CBD-rich cannabis extracts was over 4 times lower than the dose reported by patients taking purified CBD. This data suggests that CBD is 4 times “more potent” when administered in herbal form, probably because other minor compounds present in the extract may contribute to its therapeutic effect. The interpretation of higher potency of CBD in combination with other minor compounds is in line with previous reports of synergistic effects between cannabinoid and even non-cannabinoid compounds.” In addition to CBD, minor cannabinoids, including cannabidivarin (CBDV), tetrahydrocannabivarin (THCV), and cannabinol (CBN) also appear to have anti-convulsant properties. Pamplona F, da Silva L and Coan A. Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis. Front. Neurol., 12 September 2018 Sec.Neuropharmacology https://doi.org/10.3389/fneur.2018.00759
2025-10-30
Are cannabinoids absorbed to the same extent with smoking compared to vaporizing?
No. When ingesting marijuana via a vaporizer, the user absorbs up to 33% of the total cannabinoids present in herbal mixture. When smoking, an individual typically absorbs about 25% of the cannabinoids present in herbal mixture. Peters J, Chien J. Contemporary Routes of Cannabis Consumption: A Primer for Clinicians. The Journal of the American Osteopathic Association, February 2018, Vol. 118, 67-70. doi: https://doi.org/10.7556/jaoa.2018.020.
2025-10-29
CBD-related liver enzyme elevations and drug-induced liver injury (DILI) have been observed at doses ≥20 mg/kg/day, especially with valproate co-administration. However, DILI was not reported at doses <300 mg/day. Is the risk of DILI significantly greater with CBD as compared to with statins?
Actually, no. The risk of DILI is comparable to or even slightly lower with CBD as compared to with statins or fluoroquinolones.Lo, LA, Christiansen, A, Eadie, L, Strickland, JC, Kim, DD, Boivin, M, et al. Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis. J Intern Med. 2023; 293: 724– 752.
2025-10-28
Does abrupt discontinuation of CBD use lead to a withdrawal syndrome?
No. In a study evaluating abuse liability of CBD, it was found that “abrupt withdrawal of CBD after 4 weeks of use (750 mg twice daily taken orally) did not result in any symptoms of physical withdrawal.” Unlike THC, CBD is not addictive. Kirkland AE, Fadus MC et al.. A scoping review of the use of cannabidiol in psychiatric disorders. Psych Resear. 308 (2022)
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