Your Dose of Cannabis Education

Your Dose of Cannabis Education

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Your Dose of Cannabis Education is based on data from the studies and reviews published in the current peer-reviewed medical journals. Whether you are a healthcare provider, patient, caregiver, an individual working in the healthcare sector, or just a curious person, you can benefit from Your Dose of Cannabis Education. 

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2024-11-21
Do oral mucosal spray cannabinoid-based medicines (CBMs) have the same bioavailability as ingested CBMs?
No. The administration of CBMs via oromucosal sprays (sublingual) avoids first-pass metabolism (although some of the product is swallowed) and therefore sublingual administration has a higher bioavailability than ingested formulations.
St. Marie R, Leo, R. “Cannabinoid-Based Medications for Pain.” Current Psychiatry. 2021 May;20(5):21-23, 28-33
2024-11-20
Is the bioavailability of THC greater with inhaled cannabinoid-based medicines (CBMs) or ingested CBMs?
The bioavailability of inhaled CBMs is nearly 30% while the bioavailability of ingested CBMs is approximately 4%-20%. (It should be noted that the bioavailability is higher with vaporized cannabis as compared with combusted (smoked) cannabis products.) Also, lipids can increase the absorption of orally administered CBD.
St. Marie R, Leo, R. “Cannabinoid-Based Medications for Pain.” Current Psychiatry. 2021 May;20(5):21-23, 28-33
2024-11-19
Have any studies compared chronic pain patients' scheduling of THC administration to that of CBD administration?
According to a survey involving 1087 adults with self-reported chronic pain using cannabis for symptom management in the USA and Canada, "THC-rich products were typically used at night, while CBD-rich products were more often used during the day."
Boehnke KF, Yakas L, Scott JR, DeJonckheere M, Litinas E, Sisley S, Clauw DJ, Williams DA, McAfee J. A mixed methods analysis of cannabis use routines for chronic pain management. J Cannabis Res. 2022 Jan 11;4(1):7.
2024-11-18
Have any studies found that some modes of cannabinoid administration are more effective than other modes of administration?
According to a survey involving 1087 adults with self-reported chronic pain using cannabis for symptom management in the USA and Canada, "participants using non-inhalation + inhalation administration routes reported larger improvements in health than the non-inhalation... and inhalation subgroups. Similarly, the non-inhalation + inhalation group had significantly more medication substitutions than those using non-inhalation.... and inhalation administration routes, respectively."
Boehnke KF, Yakas L, Scott JR, DeJonckheere M, Litinas E, Sisley S, Clauw DJ, Williams DA, McAfee J. A mixed methods analysis of cannabis use routines for chronic pain management. J Cannabis Res. 2022 Jan 11;4(1):7.
2024-11-15
Which medical cannabinoid administration routine for the treatment of chronic pain is most often employed... Is it non-inhalation, inhalation or a combination of both?
According to a survey involving 1087 adults with self-reported chronic pain using cannabis for symptom management in the USA and Canada, "18.8%, 36.2%, and 45% used non-inhalation, inhalation, and non-inhalation + inhalation routes, respectively. Those who used inhalation routes were younger (mean age 46.5 [inhalation] and 49.2 [non-inhalation + inhalation] vs. 56.3 [non-inhalation],... p<0.001), while a higher proportion of those who used non-inhalation routes were female."
Boehnke KF, Yakas L, Scott JR, DeJonckheere M, Litinas E, Sisley S, Clauw DJ, Williams DA, McAfee J. A mixed methods analysis of cannabis use routines for chronic pain management. J Cannabis Res. 2022 Jan 11;4(1):7.

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